SrasV1, Main, Exploration, bibRecord, 005B42

Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients

Identifieur interne : 005B42 ( Main/Exploration ); précédent : 005B41; suivant : 005B43

Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients

Auteurs : Nelson Lee [Hong Kong] ; K. C. Allen Chan [Hong Kong] ; David S. Hui [Hong Kong] ; Enders K. O. Ng [Hong Kong] ; Alan Wu [Hong Kong] ; Rossa W. K. Chiu [Hong Kong] ; Vincent W. S. Wong [Hong Kong] ; Paul K. S. Chan [Hong Kong] ; K. T. Wong [Hong Kong] ; Eric Wong [Hong Kong] ; C. S. Cockram [Hong Kong] ; John S. Tamp [Hong Kong] ; Joseph J. Y. Sung [Hong Kong] ; Y. M. Dennis Lo [Hong Kong]

Source :

Journal of clinical virology [ 1386-6532 ] ; 2004.

RBID : Pascal:04-0594552

Descripteurs français

KwdFr :
- ARN viral (sang), Adulte, Charge virale, Coronavirus (génétique), Hormones corticosurrénaliennes (effets indésirables), Hormones corticosurrénaliennes (usage thérapeutique), Humains, Méthode en double aveugle, Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (sang), Syndrome respiratoire aigu sévère (traitement médicamenteux), Virus du SRAS (génétique), Virus du SRAS (physiologie), Études prospectives.
MESH :
- diagnostic : Syndrome respiratoire aigu sévère.
- effets indésirables : Hormones corticosurrénaliennes.
- génétique : Coronavirus, Virus du SRAS.
- physiologie : Virus du SRAS.
- sang : ARN viral, Syndrome respiratoire aigu sévère.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Hormones corticosurrénaliennes.
Pascal (Inist)
- Adulte, Charge virale, Coronavirus, Homme, Humains, Méthode en double aveugle, Précoce, Corticostéroïde, Traitement, Plasma sanguin, RNA, Concentration, Adulte, Charge virale, Syndrome respiratoire aigu sévère, Microbiologie, Virologie, Virus syndrome respiratoire aigu sévère, Études prospectives.
Wicri :
- topic : Homme, Adulte.

English descriptors

KwdEn :
- Adrenal Cortex Hormones (adverse effects), Adrenal Cortex Hormones (therapeutic use), Adult, Blood plasma, Concentration, Coronavirus, Coronavirus (genetics), Corticosteroid, Double-Blind Method, Early, Human, Humans, Microbiology, Prospective Studies, RNA, RNA, Viral (blood), SARS Virus (genetics), SARS Virus (physiology), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (drug therapy), Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Treatment, Viral Load, Viral load, Virology.
MESH :
- chemical , adverse effects : Adrenal Cortex Hormones.
- chemical , blood : RNA, Viral.
- chemical , therapeutic use : Adrenal Cortex Hormones.
- blood : Severe Acute Respiratory Syndrome.
- diagnosis : Severe Acute Respiratory Syndrome.
- drug therapy : Severe Acute Respiratory Syndrome.
- genetics : Coronavirus, SARS Virus.
- physiology : SARS Virus.
- Adult, Double-Blind Method, Humans, Prospective Studies, Viral Load.

Abstract

Background: The effect of corticosteroid treatment on the viral load of Severe Acute Respiratory Syndrome (SARS) patients is unknown. Objective: To compare the plasma SARS-CoV RNA concentrations in ribavirin-treated patients who received early hydrocortisone therapy with those who received placebo. Study design: Serial plasma SARS-CoV RNA concentrations measured in the setting of a prospective, randomized double-blinded, placebo-controlled trial designed to assess the efficacy of "early" (<7 days of illness) hydrocortisone use in previously healthy SARS patients were analyzed. SARS-CoV RNA was quantified using a one-step real-time RT-PCR assay targeting the nucleocapsid gene. Results: Among 16 non-ICU cases, SARS-CoV RNA was detected in plasma since day 3-4 after fever onset; viral concentration peaked in the first week, which then rapidly declined in the second week of illness. On days 8, 12, 16, and 20, the cumulative proportion of patients with undetectable virus in plasma was 31%, 69%, 92%, and 100%, respectively. Plasma SARS-CoV RNA concentrations in the second and third week of illness were significantly higher in patients who received initial hydrocortisone treatment (n = 9), as compared to those who received placebo (n = 7)(AUC; Mann-Whitney, P = 0.023). The median time for SARS-CoV to become undetectable in plasma was 12 days (11-20 days) versus 8 days (8-15 days), respectively. Conclusion: Our findings suggested "early" corticosteroid treatment was associated with a higher subsequent plasma viral load.

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients</title>
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<author><name sortKey="Wong, K T" sort="Wong, K T" uniqKey="Wong K" first="K. T." last="Wong">K. T. Wong</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Wong, Eric" sort="Wong, Eric" uniqKey="Wong E" first="Eric" last="Wong">Eric Wong</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Center for Epidemiology and Biostatistics, School of Public Health, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Cockram, C S" sort="Cockram, C S" uniqKey="Cockram C" first="C. S." last="Cockram">C. S. Cockram</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Tamp, John S" sort="Tamp, John S" uniqKey="Tamp J" first="John S." last="Tamp">John S. Tamp</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Micrcbiology, Prince of Wales Hospital, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Lo, Y M Dennis" sort="Lo, Y M Dennis" uniqKey="Lo Y" first="Y. M. Dennis" last="Lo">Y. M. Dennis Lo</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Room 38023, I/F Clinical Sciences Building, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong Special Administrative Region</s1>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Room 38023, I/F Clinical Sciences Building, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong Special Administrative Region</wicri:noRegion>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of clinical virology</title>
<title level="j" type="abbreviated">J. clin. virol.</title>
<idno type="ISSN">1386-6532</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of clinical virology</title>
<title level="j" type="abbreviated">J. clin. virol.</title>
<idno type="ISSN">1386-6532</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Hormones (adverse effects)</term>
<term>Adrenal Cortex Hormones (therapeutic use)</term>
<term>Adult</term>
<term>Blood plasma</term>
<term>Concentration</term>
<term>Coronavirus</term>
<term>Coronavirus (genetics)</term>
<term>Corticosteroid</term>
<term>Double-Blind Method</term>
<term>Early</term>
<term>Human</term>
<term>Humans</term>
<term>Microbiology</term>
<term>Prospective Studies</term>
<term>RNA</term>
<term>RNA, Viral (blood)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (physiology)</term>
<term>Severe Acute Respiratory Syndrome (blood)</term>
<term>Severe Acute Respiratory Syndrome (diagnosis)</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
<term>Severe acute respiratory syndrome</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Treatment</term>
<term>Viral Load</term>
<term>Viral load</term>
<term>Virology</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (sang)</term>
<term>Adulte</term>
<term>Charge virale</term>
<term>Coronavirus (génétique)</term>
<term>Hormones corticosurrénaliennes (effets indésirables)</term>
<term>Hormones corticosurrénaliennes (usage thérapeutique)</term>
<term>Humains</term>
<term>Méthode en double aveugle</term>
<term>Syndrome respiratoire aigu sévère (diagnostic)</term>
<term>Syndrome respiratoire aigu sévère (sang)</term>
<term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (physiologie)</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Adrenal Cortex Hormones</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Hormones corticosurrénaliennes</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hormones corticosurrénaliennes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Double-Blind Method</term>
<term>Humans</term>
<term>Prospective Studies</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Charge virale</term>
<term>Coronavirus</term>
<term>Homme</term>
<term>Humains</term>
<term>Méthode en double aveugle</term>
<term>Précoce</term>
<term>Corticostéroïde</term>
<term>Traitement</term>
<term>Plasma sanguin</term>
<term>RNA</term>
<term>Concentration</term>
<term>Adulte</term>
<term>Charge virale</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Microbiologie</term>
<term>Virologie</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Adulte</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: The effect of corticosteroid treatment on the viral load of Severe Acute Respiratory Syndrome (SARS) patients is unknown. Objective: To compare the plasma SARS-CoV RNA concentrations in ribavirin-treated patients who received early hydrocortisone therapy with those who received placebo. Study design: Serial plasma SARS-CoV RNA concentrations measured in the setting of a prospective, randomized double-blinded, placebo-controlled trial designed to assess the efficacy of "early" (<7 days of illness) hydrocortisone use in previously healthy SARS patients were analyzed. SARS-CoV RNA was quantified using a one-step real-time RT-PCR assay targeting the nucleocapsid gene. Results: Among 16 non-ICU cases, SARS-CoV RNA was detected in plasma since day 3-4 after fever onset; viral concentration peaked in the first week, which then rapidly declined in the second week of illness. On days 8, 12, 16, and 20, the cumulative proportion of patients with undetectable virus in plasma was 31%, 69%, 92%, and 100%, respectively. Plasma SARS-CoV RNA concentrations in the second and third week of illness were significantly higher in patients who received initial hydrocortisone treatment (n = 9), as compared to those who received placebo (n = 7)(AUC; Mann-Whitney, P = 0.023). The median time for SARS-CoV to become undetectable in plasma was 12 days (11-20 days) versus 8 days (8-15 days), respectively. Conclusion: Our findings suggested "early" corticosteroid treatment was associated with a higher subsequent plasma viral load.</div>
</front>
</TEI>
<affiliations><list><country><li>Hong Kong</li>
</country>
<settlement><li>Sha Tin</li>
</settlement>
<orgName><li>Université chinoise de Hong Kong</li>
</orgName>
</list>
<tree><country name="Hong Kong"><noRegion><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name>
</noRegion>
<name sortKey="Chan, K C Allen" sort="Chan, K C Allen" uniqKey="Chan K" first="K. C. Allen" last="Chan">K. C. Allen Chan</name>
<name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name>
<name sortKey="Chiu, Rossa W K" sort="Chiu, Rossa W K" uniqKey="Chiu R" first="Rossa W. K." last="Chiu">Rossa W. K. Chiu</name>
<name sortKey="Cockram, C S" sort="Cockram, C S" uniqKey="Cockram C" first="C. S." last="Cockram">C. S. Cockram</name>
<name sortKey="Hui, David S" sort="Hui, David S" uniqKey="Hui D" first="David S." last="Hui">David S. Hui</name>
<name sortKey="Lo, Y M Dennis" sort="Lo, Y M Dennis" uniqKey="Lo Y" first="Y. M. Dennis" last="Lo">Y. M. Dennis Lo</name>
<name sortKey="Ng, Enders K O" sort="Ng, Enders K O" uniqKey="Ng E" first="Enders K. O." last="Ng">Enders K. O. Ng</name>
<name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name>
<name sortKey="Tamp, John S" sort="Tamp, John S" uniqKey="Tamp J" first="John S." last="Tamp">John S. Tamp</name>
<name sortKey="Wong, Eric" sort="Wong, Eric" uniqKey="Wong E" first="Eric" last="Wong">Eric Wong</name>
<name sortKey="Wong, K T" sort="Wong, K T" uniqKey="Wong K" first="K. T." last="Wong">K. T. Wong</name>
<name sortKey="Wong, Vincent W S" sort="Wong, Vincent W S" uniqKey="Wong V" first="Vincent W. S." last="Wong">Vincent W. S. Wong</name>
<name sortKey="Wu, Alan" sort="Wu, Alan" uniqKey="Wu A" first="Alan" last="Wu">Alan Wu</name>
</country>
</tree>
</affiliations>
</record>

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Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients

Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients

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